When do gout attacks typically occur? (Commonly at night or early morning)

雷 杨
雷 杨
Patient advocate for gout awareness and management.

That's right, many people are woken up by pain in the middle of the night or early morning, which is a very typical characteristic of gout.

You can understand it this way: several reasons combine to cause this:

  1. Dehydration: When we sleep at night, we don't drink water for several hours, but the body still loses water through breathing and sweating. As a result, the water content in the blood decreases, and the concentration of uric acid increases. It's like a pot of soup: when the water boils away, the salt naturally becomes more concentrated. The higher the uric acid concentration, the more easily it crystallizes.

  2. Lower Body Temperature: After a person falls asleep, body temperature is slightly lower than during the day. Uric acid has a peculiar characteristic: it's less soluble in cold temperatures. When the temperature drops, its solubility in the blood decreases, making it more likely to 'escape' and form needle-like crystals that prick your joints.

  3. Hormonal Changes: Our body has a hormone called 'cortisol,' which helps suppress inflammation; it's a natural 'anti-inflammatory drug.' However, this hormone is secreted least at night. With uric acid crystals causing trouble in the joints and the body's natural 'anti-inflammatory drug' being insufficient, inflammation suddenly erupts, and severe pain follows.

So, when these factors combine, it leads to gout particularly liking to 'ambush' you in the dead of night.