When do gout attacks typically occur? (Commonly at night or early morning)
That's right, many people are woken up by pain in the middle of the night or early morning, which is a very typical characteristic of gout.
You can understand it this way: several reasons combine to cause this:
-
Dehydration: When we sleep at night, we don't drink water for several hours, but the body still loses water through breathing and sweating. As a result, the water content in the blood decreases, and the concentration of uric acid increases. It's like a pot of soup: when the water boils away, the salt naturally becomes more concentrated. The higher the uric acid concentration, the more easily it crystallizes.
-
Lower Body Temperature: After a person falls asleep, body temperature is slightly lower than during the day. Uric acid has a peculiar characteristic: it's less soluble in cold temperatures. When the temperature drops, its solubility in the blood decreases, making it more likely to 'escape' and form needle-like crystals that prick your joints.
-
Hormonal Changes: Our body has a hormone called 'cortisol,' which helps suppress inflammation; it's a natural 'anti-inflammatory drug.' However, this hormone is secreted least at night. With uric acid crystals causing trouble in the joints and the body's natural 'anti-inflammatory drug' being insufficient, inflammation suddenly erupts, and severe pain follows.
So, when these factors combine, it leads to gout particularly liking to 'ambush' you in the dead of night.